Revealing Molecular Mechanisms by Integrating High-Dimensional Functional Screens with Protein Interaction Data.
Angela SimeoneGiovanni MarsicoClaudio CollinetThierry GalvezYannis KalaidzidisMarino ZerialAndreas BeyerPublished in: PLoS Comput. Biol. (2014)
Keyphrases
- protein interaction data
- high dimensional
- protein protein interactions
- protein function prediction
- protein interaction
- gene expression data
- genomic data
- protein function
- high throughput
- low dimensional
- microarray
- nearest neighbor
- protein complexes
- computational methods
- high dimensionality
- high precision
- gene expression
- dimensionality reduction
- data points
- feature space
- data sets
- gene ontology
- gene regulatory networks
- biomedical literature
- biological processes
- protein interaction networks
- computational approaches
- systems biology
- biological systems
- functional modules