Plug & play directed evolution of proteins with gradient-based discrete MCMC.
Patrick EmamiAidan PerreaultJeffrey N. LawDavid BiagioniPeter C. St. JohnPublished in: Mach. Learn. Sci. Technol. (2023)
Keyphrases
- markov chain
- monte carlo
- protein sequences
- markov chain monte carlo
- protein protein interactions
- sequence similarity
- discrete space
- amino acids
- protein structure
- bayesian inference
- data association
- generative model
- functional modules
- protein interaction networks
- simulated annealing
- protein function
- living cells
- least squares