Modular and tunable biological feedback control using a de novo protein switch.
Andrew H. NgTaylor H. NguyenMariana Gómez-SchiavonGalen DodsRobert A. LanganScott E. BoykenJennifer A. SamsonLucas M. WaldburgerJohn E. DueberDavid BakerHana El-SamadPublished in: Nat. (2019)
Keyphrases
- feedback control
- tandem mass spectra
- mass spectra
- mass spectrometry
- protein structure prediction
- closed loop
- drosophila melanogaster
- tandem mass spectrometry
- drug discovery
- optimal control
- regulatory networks
- adaptive control
- protein interaction data
- protein interaction
- open loop
- physicochemical properties
- drug design
- protein sequences
- protein complexes
- binding sites
- amino acids
- genomic sequences
- protein structure
- interaction networks
- biological entities
- protein protein interaction networks
- gene expression
- high throughput
- autonomous control
- biological systems
- linear time invariant
- protein function
- networked control systems
- motif finding
- protein interaction networks
- real time
- motif discovery
- protein families
- biological data
- systems biology
- dynamic programming
- machine learning
- biological knowledge
- functional modules
- biological processes
- human genome
- secondary structure