Genome-Wide Signatures of Transcription Factor Activity: Connecting Transcription Factors, Disease, and Small Molecules.
Jing ChenZhen HuMukta PhatakJohn ReichardJohannes M. FreudenbergSiva SivaganesanMario MedvedovicPublished in: PLoS Comput. Biol. (2013)
Keyphrases
- transcription factors
- genome wide
- high throughput
- dna binding
- differential expression
- regulatory networks
- gene sets
- human genome
- gene regulation
- microarray
- binding sites
- expression profiles
- cell cycle
- biological processes
- component analysis
- signaling pathways
- single nucleotide polymorphisms
- saccharomyces cerevisiae
- motif discovery
- dna sequences
- transcription factor binding sites
- gene expression
- chip seq
- systems biology
- computational biology
- co occurrence
- biological data
- blind source separation