Predicting target-ligand interactions using protein ligand-binding site and ligand substructures.
Caihua WangJuan LiuFei LuoZixing DengQian-Nan HuPublished in: BMC Syst. Biol. (2015)
Keyphrases
- protein protein
- virtual screening
- predicting protein
- binding sites
- protein protein interactions
- computational methods
- high throughput
- interaction networks
- protein sequences
- drug design
- protein structure
- protein complexes
- drug discovery
- protein function
- protein interaction
- dna binding
- similarity searching
- molecular biology
- secondary structure
- gene expression
- transcription factors
- biological processes
- sequence alignment
- computational approaches
- protein structure prediction
- gene ontology
- amino acid sequences
- sequence data
- biological data
- dna sequences
- functional modules
- motif discovery
- mass spectrometry
- scoring function
- network analysis
- network topology
- similarity measure