Challenges Predicting Ligand-Receptor Interactions of Promiscuous Proteins: The Nuclear Receptor PXR.
Sean EkinsSandhya KortagereManisha IyerErica J. ReschlyMarkus A. LillMatthew R. RedinboMatthew D. KrasowskiPublished in: PLoS Comput. Biol. (2009)
Keyphrases
- drug discovery
- protein protein
- drug design
- signaling pathways
- predicting protein
- protein protein interactions
- chemical compounds
- lessons learned
- subcellular localization
- interaction networks
- computational methods
- living cells
- high throughput
- interactive systems
- amino acids
- protein sequences
- open issues
- mass spectrometry
- protein structure
- key issues
- virtual screening
- social networks