Systems Biology-Based Investigation of Cellular Antiviral Drug Targets Identified by Gene-Trap Insertional Mutagenesis.
Feixiong ChengJames L. MurrayJunfei ZhaoJinsong ShengZhongming ZhaoDonald H. RubinPublished in: PLoS Comput. Biol. (2016)
Keyphrases
- systems biology
- gene regulatory networks
- drug discovery
- interaction networks
- high throughput
- gene regulation
- signaling pathways
- cell cycle
- regulatory networks
- biological processes
- microarray
- gene networks
- genetic networks
- biochemical networks
- biological data
- genome scale
- biological networks
- gene expression data
- biological systems
- gene expression
- molecular biology
- protein protein interactions
- protein interaction
- computational methods
- network model
- metabolic pathways
- reverse engineering
- computational biology
- life sciences
- biological knowledge
- bayesian inference
- machine learning
- protein protein interaction networks
- genome wide
- high dimensionality
- knowledge discovery
- bayesian networks