Predicting gene targets of perturbations via network-based filtering of mRNA expression compendia.
Elissa J. CosgroveYingchun ZhouTimothy S. GardnerEric D. KolaczykPublished in: Bioinform. (2008)
Keyphrases
- expression profiles
- post transcriptional
- gene expression
- microarray
- gene regulation
- gene expression profiles
- genome wide
- differential expression
- gene regulatory networks
- gene expression data
- splice site
- regulatory networks
- gene networks
- gene function
- gene prediction
- gene sets
- microarray data
- meta analysis
- high throughput
- cellular processes
- cell cycle
- protein protein interactions
- cis regulatory
- gene expression patterns
- systems biology
- alternative splicing
- sequence data
- biological processes
- microarray datasets
- gene ontology
- network model
- filtering algorithm
- predicting protein
- molecular biology
- multiple targets
- biological systems
- gene selection
- binding sites
- high dimensionality
- high dimensional
- sequence analysis
- genomic data
- dna sequences
- human genome
- transcription factors