Hydration Properties of Ligands and Drugs in Protein Binding Sites: Tightly-Bound, Bridging Water Molecules and Their Effects and Consequences on Molecular Design Strategies.
Alfonso T. García-SosaPublished in: J. Chem. Inf. Model. (2013)
Keyphrases
- virtual screening
- binding sites
- drug discovery
- gene expression
- dna sequences
- similarity searching
- transcription factors
- sequence data
- protein protein
- drug design
- statistical significance
- dna binding
- motif discovery
- high throughput
- sequence alignment
- biological sequences
- regulatory elements
- similarity search
- protein interaction
- microarray
- coding regions
- upper bound
- drosophila melanogaster
- pairwise