Identification of novel inhibitors for Pim-1 kinase using pharmacophore modeling based on a novel method for selecting pharmacophore generation subsets.
Rand ShahinLubna SwellmeenOmar ShaheenNour AboalhaijaMaha HabashPublished in: J. Comput. Aided Mol. Des. (2016)
Keyphrases
- significant improvement
- experimental evaluation
- high accuracy
- identification rate
- generation method
- dynamic programming
- cost function
- preprocessing
- computational cost
- classification method
- synthetic data
- clustering method
- machine learning
- pairwise
- drug discovery
- learning algorithm
- modeling method
- high precision
- detection method
- detection algorithm
- segmentation algorithm
- support vector machine svm
- input data
- data sets
- support vector machine
- probabilistic model
- objective function