Perturbation biology links temporal protein changes to drug responses in a melanoma cell line.
Elin NymanRichard R. SteinXiaohong JingWeiqing WangBenjamin MarksIoannis K. ZervantonakisAnil KorkutNicholas Paul GauthierChris SanderPublished in: PLoS Comput. Biol. (2020)
Keyphrases
- drug discovery
- protein structure prediction
- drug design
- chemical compounds
- virtual screening
- cellular processes
- temporal constraints
- spatio temporal
- temporal information
- temporal data
- spatial and temporal
- physico chemical
- protein structure
- protein sequences
- signaling pathways
- cell lines
- line segments
- systems biology
- molecular biology
- mass spectrometry
- contact map
- subcellular localization
- link analysis
- mathematical modeling
- similarity searching
- graph theory
- temporal reasoning