Structure-based ligand design by a build-up approach and genetic algorithm search in conformational space.
Nicolas BudinNicolas MajeuxCatherine Tenette-SouailleAmedeo CaflischPublished in: J. Comput. Chem. (2001)
Keyphrases
- genetic algorithm
- search space
- search algorithm
- design space
- genetic search
- building blocks
- low dimensional
- design process
- solution space
- structural properties
- search capabilities
- neural network
- evolutionary algorithm
- web search
- artificial neural networks
- ant colony optimization
- design principles
- information space
- web pages