Differential DNA repair underlies mutation hotspots at active promoters in cancer genomes.
Dilmi PereraRebecca C. PoulosAnushi ShahDominik BeckJohn E. PimandaJason W. H. WongPublished in: Nat. (2016)
Keyphrases
- sequence analysis
- binding sites
- escherichia coli
- genomic sequences
- sequence data
- dna sequences
- sequenced genomes
- genome sequences
- genetic algorithm
- nucleotide sequences
- coding regions
- breast cancer
- human genome
- phylogenetic analysis
- dna computing
- early detection
- evolutionary algorithm
- rna sequences
- differential evolution
- gene expression
- fitness function
- cis regulatory
- comparative genomics
- protein coding regions
- comparative analysis
- dna copy number
- gene regulation
- genomic data
- gene expression profiles
- genetic algorithm ga
- cancer diagnosis
- transcription factor binding sites
- damage assessment
- biological sequences
- transcription factors
- lung cancer
- mutation operator
- gene selection
- crossover operator
- computational biology