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Both Ligand- and Cell-Specific Parameters Control Ligand Agonism in a Kinetic Model of G Protein-Coupled Receptor Signaling.
Tamara Kinzer-Ursem
Jennifer J. Linderman
Published in:
PLoS Comput. Biol. (2007)
Keyphrases
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computational model
sensitivity analysis
parameter values
parameter estimation
experimental data
drug discovery
neural network
high level
control parameters
objective function
probability distribution
mathematical model
probability density function
autoregressive
nonlinear dynamics