Estimating the Expression of Transcript Isoforms from mRNA-Seq via Nonnegative Least Squares.
Hyunsoo KimYingtao BiRamana V. DavuluriPublished in: BIBE (2010)
Keyphrases
- rna seq
- least squares
- high throughput
- alternative splicing
- genome wide
- gene expression
- parameter estimation
- matrix approximation
- biological data
- nonnegative matrix factorization
- robust estimation
- objective function
- splice site
- statistical analysis
- data sets
- protein protein interactions
- computational methods
- high speed
- optical flow