Structural Investigations of Acridine Derivatives by CoMFA and CoMSIA Reveal Novel Insight into Their Structures toward DNA G-Quadruplex Mediated Telomerase Inhibition and Offer a Highly Predictive 3D-Model for Substituted Acridines.
Vishal Prakash ZambrePrashant Revan MurumkarRajani GiridharMange Ram YadavPublished in: J. Chem. Inf. Model. (2009)
Keyphrases
- computational model
- formal model
- probability distribution
- conceptual model
- higher order
- theoretical analysis
- mathematical model
- biologically inspired
- information retrieval
- classification models
- prediction model
- hierarchical structure
- em algorithm
- management system
- probabilistic model
- cost function
- high level
- image segmentation