Graph sparsification with parallelization to optimize the identification of causal genes and dysregulated pathways.
Jeethu V. DevasiaPriya ChandranAnjana SomanAiswarya Elezabeth MathewJaya JharwalPublished in: SAC (2019)
Keyphrases
- biological pathways
- gene expression
- directed acyclic graph
- metabolic pathways
- graph structure
- gene expression data
- parallel processing
- gene interactions
- microarray data
- genome scale
- random walk
- structured data
- graph theory
- signaling pathways
- causal models
- biological entities
- gene ontology
- bipartite graph
- experimental conditions
- gene expression profiles
- causal reasoning
- causal graph
- gene regulatory networks
- expression profiles
- bayesian networks
- weighted graph
- protein interaction data
- least squares
- high dimensional