Modeling multifunctionality of genes with secondary gene co-expression networks in human brain provides novel disease insights.
Juan A. SánchezAna L. Gil-MartinezAlejandro CisternaSonia García-RuízAlicia Gómez-PascualRegina H. ReynoldsMike A. NallsJohn HardyMina RytenJuan A. BotíaPublished in: Bioinform. (2021)
Keyphrases
- human brain
- expression profiles
- gene networks
- microarray
- gene sets
- gene expression
- gene gene
- gene expression profiles
- candidate genes
- gene regulatory networks
- disease genes
- gene function
- gene expression data
- gene expression levels
- differential expression
- gene ontology
- microarray data
- protein protein interaction networks
- differentially expressed genes
- genetic networks
- gene selection
- dna microarray
- signaling pathways
- regulatory networks
- genome wide
- information processing
- brain imaging
- high throughput
- gene clusters
- white matter
- related genes
- brain images
- gene expression analysis
- complex diseases
- biological networks
- biological entities
- gene gene interactions
- visual information processing
- diffusion tensor imaging
- protein protein interactions
- microarray datasets
- escherichia coli
- data mining
- interaction networks
- biological knowledge
- cerebral cortex
- gene expression patterns
- microarray data analysis
- systems biology
- cis regulatory
- brain regions
- cognitive functions
- functional magnetic resonance imaging
- binding sites
- biological systems
- medical images
- database systems