Seeing the trees through the forest: sequence-based homo- and heteromeric protein-protein interaction sites prediction using random forest.
Qingzhen HouPaul F. G. De GeestWim F. VrankenJaap HeringaK. Anton FeenstraPublished in: Bioinform. (2017)
Keyphrases
- random forest
- protein protein interactions
- protein complexes
- decision trees
- multiple sequence alignments
- protein interaction
- experimentally determined
- predicting protein
- random forests
- phylogenetic trees
- computational methods
- feature set
- functional modules
- ensemble classifier
- protein interaction networks
- prediction accuracy
- high throughput
- gene ontology
- protein sequences
- biological data
- ensemble methods
- computational approaches
- biological processes
- ppi networks
- biomedical literature
- genomic data
- high precision
- computational biology
- data sets
- information retrieval
- pairwise
- gene expression
- multi label
- network topology
- systems biology
- machine learning algorithms
- feature selection
- secondary structure
- data mining