Scipio: Using protein sequences to determine the precise exon/intron structures of genes and their orthologs in closely related species.
Oliver KellerFlorian OdronitzMario StankeMartin KollmarStephan WaackPublished in: BMC Bioinform. (2008)
Keyphrases
- closely related
- alternative splicing
- protein sequences
- structural motifs
- sequence data
- genome sequences
- human genome
- sequence analysis
- biological sequences
- computational biology
- essential genes
- multiple sequence alignments
- coding regions
- experimentally determined
- protein structure
- protein classification
- amino acids
- protein function
- physico chemical
- protein families
- high throughput
- multiple sequence alignment
- genome wide
- secondary structure
- comparative analysis
- amino acid sequences
- protein secondary structure
- protein structure prediction
- multiple alignment
- computational approaches
- sequence databases
- gene expression
- genome scale
- objective function
- molecular biology
- dna sequences
- linear combination