Computational Proteomics of Biomolecular Interactions in Sequence and Structure Space of the Tyrosine Kinome: Evolutionary Constraints and Protein Conformational Selection Determine Binding Signatures of Cancer Drugs.
Gennady VerkhivkerPublished in: WILF (2007)
Keyphrases
- drug design
- drug discovery
- sequence similarity
- protein structure prediction
- sequence analysis
- protein structural
- hiv protease
- protein structure
- dna binding
- protein folding
- secondary structure of proteins
- genetic algorithm
- multiple sequence alignment
- mass spectrometry
- protein interaction
- contact map
- sequence alignment
- multiple sequence alignments
- high throughput
- genomic sequences
- coarse grained
- protein protein
- mass spectra
- virtual screening
- structural motifs
- protein sequences
- breast cancer