Predicting changes in protein thermodynamic stability upon point mutation with deep 3D convolutional neural networks.
Bian LiYucheng T. YangJohn A. CapraMark B. GersteinPublished in: PLoS Comput. Biol. (2020)
Keyphrases
- convolutional neural networks
- evolutionary algorithm
- predicting protein
- genetic algorithm
- stability analysis
- neural network
- protein structure
- protein sequences
- fitness function
- differential evolution
- amino acids
- mutation operator
- experimental data
- protein structure prediction
- convolutional network
- protein interaction
- protein function
- molecular dynamics
- mass spectra
- protein interaction data
- dead end
- genetic programming