Allosteric Mechanism of the Hsp90 Chaperone Interactions with Cochaperones and Client Proteins by Modulating Communication Spines of Coupled Regulatory Switches: Integrative Atomistic Modeling of Hsp90 Signaling in Dynamic Interaction Networks.
Lindy AstlGabrielle StetzGennady M. VerkhivkerPublished in: J. Chem. Inf. Model. (2020)
Keyphrases
- interaction networks
- protein protein
- protein function
- molecular interactions
- systems biology
- biological processes
- gene regulatory networks
- high throughput
- protein protein interaction networks
- mass spectrometry
- biological networks
- protein interaction networks
- communication networks
- saccharomyces cerevisiae
- protein complexes
- gene regulation
- gene expression
- protein protein interactions
- bayesian networks
- functional modules
- protein sequences
- biological knowledge
- complex networks
- computational model