Identifying functional miRNA-mRNA regulatory modules with correspondence latent dirichlet allocation.
Bing LiuLin LiuAnna TsykinGregory J. GoodallJeffrey E. GreenMin ZhuChang-Hee KimJiuyong LiPublished in: Bioinform. (2010)
Keyphrases
- post transcriptional
- latent dirichlet allocation
- gene expression
- gene regulation
- topic models
- transcription factors
- microarray
- gene function
- gene expression data
- regulatory networks
- genome wide
- systems biology
- generative model
- lda model
- binding sites
- gene regulatory networks
- microarray data
- biological networks
- text mining
- high throughput
- functional modules
- co occurrence
- dimensionality reduction
- support vector
- computational biology
- biological systems
- biological data
- gene ontology
- network model
- dna sequences
- expression profiles
- graphical models
- saccharomyces cerevisiae
- belief propagation
- maximum likelihood
- probabilistic model
- data sets