Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases.
Sangsu BaeJeongbin ParkJin-Soo KimPublished in: Bioinform. (2014)
Keyphrases
- experimental evaluation
- learning algorithm
- times faster
- detection algorithm
- computational cost
- target tracking
- optimization algorithm
- linear programming
- theoretical analysis
- particle swarm optimization
- cost function
- dynamic programming
- high accuracy
- target object
- k means
- convergence rate
- matching algorithm
- ant colony optimization
- genetic algorithm
- similarity measure
- microarray
- clustering method
- objective function
- optimal solution
- search space
- computationally efficient
- neural network
- worst case