A comparison of curated gene sets versus transcriptomics-derived gene signatures for detecting pathway activation in immune cells.
Bin LiuPatrick LindnerAdan Chari JirmoUlrich MausThomas IlligDavid S. DeLucaPublished in: BMC Bioinform. (2020)
Keyphrases
- gene sets
- gene ontology
- microarray
- gene clusters
- microarray data
- immune cells
- biologically meaningful
- statistical significance
- biomedical literature
- gene expression
- gene selection
- protein protein interactions
- high throughput
- metabolic pathways
- regulatory networks
- fold cross validation
- transcription factors
- gene expression analysis
- data sets
- gene networks
- gene expression data
- immune response
- information theoretic