Biophysical Fitness Landscapes for Transcription Factor Binding Sites.
Allan HaldaneMichael ManhartAlexandre V. MorozovPublished in: PLoS Comput. Biol. (2014)
Keyphrases
- transcription factor binding sites
- fitness landscape
- dna sequences
- binding sites
- evolutionary algorithm
- genetic algorithm
- transcription factors
- fitness function
- genetic programming
- motif discovery
- human genome
- data sets
- gene expression
- genome wide
- feature space
- dna binding
- gene regulation
- computational biology
- sequence data
- microarray
- multi objective
- data mining