Expanding the Druggable Space of the LSD1/CoREST Epigenetic Target: New Potential Binding Regions for Drug-Like Molecules, Peptides, Protein Partners, and Chromatin.
James C. RobertsonNate C. HurleyMarcello TortoriciGiuseppe CiossaniMaria Teresa BorrelloNadeem A. VelloreA. GanesanAndrea MatteviRiccardo BaronPublished in: PLoS Comput. Biol. (2013)
Keyphrases
- drug discovery
- pharmaceutical industry
- virtual screening
- chemical compounds
- amino acids
- mass spectrometry data
- mass spectrometry
- tandem mass spectra
- binding peptides
- mass spectra
- transcription factor binding sites
- hiv protease
- similarity searching
- high throughput
- drug design
- transcription factors
- binding sites
- parameter space
- chemical reactions
- ms ms
- molecular structures
- physico chemical
- tandem mass spectrometry
- protein structure