A Provable and Efficient Ensemble-Based Protein Design Algorithm to Optimize Stability and Binding Affinity Over Large Sequence Spaces.
Adegoke OjewoleJonathan D. JouVance G. FowlerBruce Randall DonaldPublished in: J. Comput. Biol. (2018)
Keyphrases
- learning algorithm
- detection algorithm
- single pass
- optimal solution
- computational complexity
- k means
- computationally efficient
- probabilistic model
- sequence alignment
- input data
- neural network
- dynamic programming
- np hard
- search space
- objective function
- lower bound
- worst case
- simulated annealing
- segmentation algorithm
- decision trees
- design space
- feature selection
- rna secondary structures
- protein structure alignment