The Landscape of the Prion Protein's Structural Response to Mutation Revealed by Principal Component Analysis of Multiple NMR Ensembles.
Deena M. A. GendooPaul M. HarrisonPublished in: PLoS Comput. Biol. (2012)
Keyphrases
- principal component analysis
- protein structure
- evolutionary algorithm
- protein backbone
- nuclear magnetic resonance
- structural information
- genetic algorithm
- differential evolution
- highly accurate
- independent component analysis
- ensemble methods
- tandem mass spectrometry
- neural network
- protein interaction
- linear discriminant analysis
- covariance matrix
- low dimensional
- feature extraction
- computer vision