Drug-target affinity prediction method based on multi-scale information interaction and graph optimization.
Zhiqin ZhuZheng YaoXin ZhengGuanqiu QiYuanyuan LiNeal MazurXinbo GaoYifei GongBaisen CongPublished in: Comput. Biol. Medicine (2023)
Keyphrases
- multiscale
- optimization algorithm
- high accuracy
- computational complexity
- pairwise
- optimization method
- prior knowledge
- user interaction
- optimization process
- significant improvement
- similarity measure
- prediction model
- optimization model
- statistical information
- prior information
- information seeking
- graph representation
- constrained optimization
- topological information
- topological map
- graph structures
- neural network
- clustering method
- random walk
- cost function
- search engine
- graph matching
- prediction error
- semi supervised
- information extraction
- dynamic programming
- k means
- image sequences