Design of stapled DNA-minor-groove-binding molecules with a mutable atom simulated annealing method.
Wynn L. WalkerMary L. KopkaRichard E. DickersonDavid S. GoodsellPublished in: J. Comput. Aided Mol. Des. (1997)
Keyphrases
- high accuracy
- detection method
- simulated annealing
- computational cost
- experimental evaluation
- synthetic data
- prior knowledge
- preprocessing
- optimization method
- probabilistic model
- objective function
- input data
- segmentation method
- image sequences
- neural network
- combinatorial optimization
- hill climbing
- dna sequences
- clustering method
- support vector machine svm
- model selection
- significant improvement
- user interface
- bayesian networks
- case study