A bioinformatics approach reveals novel interactions of the OVOL transcription factors in the regulation of epithelial - mesenchymal cell reprogramming and cancer progression.
Hernan RocaManjusha PandeJeffrey S. HuoJames HernandezJames D. CavalcoliKenneth J. PientaRichard C. McEachinPublished in: BMC Syst. Biol. (2014)
Keyphrases
- transcriptional regulation
- transcription factors
- signaling pathways
- cellular processes
- cell cycle
- gene expression
- microarray
- binding sites
- systems biology
- genome wide
- saccharomyces cerevisiae
- high throughput
- differential expression
- component analysis
- computational biology
- dna sequences
- gene selection
- gene expression profiles
- regulatory elements
- computational methods
- regulatory networks
- gene regulation
- dna binding
- protein protein interaction networks
- co occurrence
- gene sets
- sequence data
- biological processes
- gene expression data
- microarray data
- cancer diagnosis
- biomedical literature
- protein protein interactions
- highly correlated
- cancer classification
- post transcriptional
- motif discovery
- gene regulatory networks
- text mining
- biological data
- molecular biology
- transcription factor binding sites
- biological sequences
- information retrieval
- data analysis
- gene ontology
- data mining
- biological systems
- protein sequences