A network-based drug repositioning infrastructure for precision cancer medicine through targeting significantly mutated genes in the human cancer genomes.
Feixiong ChengJunfei ZhaoMichaela FooksaZhongming ZhaoPublished in: J. Am. Medical Informatics Assoc. (2016)
Keyphrases
- gene selection
- cancer diagnosis
- gene expression profiles
- dna microarray
- breast cancer
- cancer classification
- microarray data
- colon cancer
- gene expression data
- cancer datasets
- gene expression
- cell lines
- gene expression datasets
- microarray
- drug discovery
- evolutionary history
- candidate genes
- genomic data
- comparative analysis
- genomic sequences
- microarray technology
- molecular biology
- related genes
- tissue samples
- prostate cancer
- gene ontology terms
- gene sets
- human genome
- gene clusters
- experimental conditions
- ovarian cancer
- gene regulatory networks
- high precision
- biologically significant
- sequenced genomes