Exploring binding positions and backbone conformations of peptide ligands of proteins with a backbone-centred statistical energy function.
Lu ZhangHaiyan LiuPublished in: J. Comput. Aided Mol. Des. (2023)
Keyphrases
- energy function
- protein backbone
- amino acids
- protein structure
- energy minimization
- graph cuts
- highly accurate
- protein sequences
- markov random field
- protein structure prediction
- secondary structure
- image intensity
- active contours
- drug design
- shape model
- global minimum
- hopfield neural network
- protein folding
- problems in computer vision
- image segmentation
- amino acid sequences
- protein function
- nuclear magnetic resonance
- level set
- energy landscape
- belief propagation
- computational biology
- maximum a posteriori
- reconstruction process
- segmentation method
- segmentation algorithm
- regularization term
- statistical methods
- mass spectrometry
- bayesian networks
- genetic algorithm