Utilizing identity-by-descent probabilities for genetic fine-mapping in population based samples, via spatial smoothing of haplotype effects.
Linda HartmanOla HössjerKeith HumphreysPublished in: Comput. Stat. Data Anal. (2009)
Keyphrases
- linkage disequilibrium
- haplotype inference
- human genome
- spatial and temporal
- genetic algorithm
- spatio temporal
- data sets
- entropy minimization
- spatial data
- spatial information
- coarse to fine
- probability distribution
- particle swarm optimization
- spatial databases
- neural network
- lower bound
- training samples
- simulated annealing
- conditional probabilities
- branch and bound algorithm
- combinatorial optimization
- differential evolution
- genome wide
- decision trees
- sample points
- multi population
- space time