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ProfNet, a method to derive profile-profile alignment scoring functions that improves the alignments of distantly related proteins.

Tomas OhlsonArne Elofsson
Published in: BMC Bioinform. (2005)
Keyphrases
  • pairwise
  • scoring functions
  • similarity measure
  • training data
  • reinforcement learning
  • probabilistic model
  • em algorithm
  • multiple sequence alignment
  • global alignment