Deep generative model for drug design from protein target sequence.
Yangyang ChenZixu WangLei WangJianmin WangPengyong LiDongsheng CaoXiangxiang ZengXiucai YeTetsuya SakuraiPublished in: J. Cheminformatics (2023)
Keyphrases
- generative model
- drug design
- protein structure prediction
- probabilistic model
- essential proteins
- drug discovery
- pitman yor process
- prior knowledge
- protein protein interactions
- em algorithm
- sequence alignment
- topic models
- semi supervised
- protein sequences
- expectation maximization
- quantitative structure activity
- data analysis