Structural assessment of the effects of Amino Acid Substitutions on protein stability and protein-protein interaction.
Shaolei TengAnand K. SrivastavaCharles E. SchwartzEmil AlexovLiangjiang WangPublished in: Int. J. Comput. Biol. Drug Des. (2010)
Keyphrases
- protein function
- amino acids
- protein protein interactions
- experimentally determined
- predicting protein
- secondary structure
- protein sequences
- sequence alignment
- protein protein
- protein structure prediction
- amino acid sequences
- protein interaction
- protein structure
- drug design
- protein complexes
- high throughput
- sequence similarity
- computational methods
- protein folding
- network topology
- high precision
- biological processes
- multiple sequence alignments
- predicting protein protein interactions
- gene ontology
- protein interaction networks
- functional modules
- biomedical literature
- structural properties
- biological data
- protein interaction data
- network analysis
- computational approaches
- genomic data
- interaction networks
- biological networks
- computational biology
- physicochemical properties
- pairwise
- cellular processes
- contact map
- protein families