Identifying Transcription Factors and microRNAs as Key Regulators of Pathways Using Bayesian Inference on Known Pathway Structures.
Damian RoqueiroLei HuangYang DaiPublished in: BIBM (2011)
Keyphrases
- transcription factors
- bayesian inference
- binding sites
- signaling pathways
- gene regulation
- regulatory networks
- gene expression
- systems biology
- dna sequences
- genome wide
- transcriptional regulatory
- prior information
- microarray
- sequence data
- high throughput
- gene regulatory networks
- probabilistic model
- component analysis
- computational biology
- motif discovery
- cell cycle
- differential expression
- saccharomyces cerevisiae
- transcriptional regulation
- biological processes
- dna binding
- particle filter
- post transcriptional
- co occurrence
- statistical significance
- transcription factor binding sites
- regulatory elements
- prior knowledge
- computational methods
- feature selection
- knowledge discovery
- bayesian networks
- gene sets
- biomedical literature
- information extraction
- natural language processing
- protein protein interactions
- gene expression data