Experimental validation of FINDSITEcomb virtual ligand screening results for eight proteins yields novel nanomolar and micromolar binders.
Bharath SrinivasanHongyi ZhouJulia KubanekJeffrey SkolnickPublished in: J. Cheminformatics (2014)
Keyphrases
- drug discovery
- drug design
- protein protein
- chemical compounds
- protein protein interactions
- subcellular localization
- protein sequences
- protein function
- virtual world
- computational methods
- virtual environment
- high throughput
- mass spectrometry
- interaction networks
- image analysis
- protein complexes
- binding sites
- amino acids
- data mining
- systems biology
- scientific data
- virtual screening