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Estimation of relative free energies of binding using pre-computed ensembles based on the single-step free energy perturbation and the site-identification by Ligand competitive saturation approaches.

E. Prabhu RamanSirish Kaushik LakkarajuRajiah A. DennyAlexander D. MacKerell Jr.
Published in: J. Comput. Chem. (2017)
Keyphrases
  • single step
  • pre computed
  • free energy
  • energy function
  • markov random field
  • fixed point
  • energy minimization
  • posterior distribution
  • multi step