Cheminformatics-aided discovery of small-molecule Protein-Protein Interaction (PPI) dual inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL).
Georgia MelagrakiEvangelos NtougkosVagelis RinotasChristos PapaneophytouGeorgios LeonisThomas M. MavromoustakosGeorge KontopidisEleni DouniAntreas AfantitisGeorge KolliasPublished in: PLoS Comput. Biol. (2017)
Keyphrases
- protein protein interactions
- protein protein
- high throughput
- drug design
- drug discovery
- systems biology
- computational methods
- predicting protein protein interactions
- biological processes
- protein interaction
- network topology
- wet lab
- predicting protein
- protein complexes
- gene ontology
- biomedical literature
- genomic data
- biological data
- protein function
- network analysis
- ppi networks
- cell cycle
- functional modules
- biological networks
- structural properties
- signaling pathways
- high precision
- microarray
- computational approaches
- protein interaction networks
- protein function prediction
- protein interaction data
- regulatory networks
- knowledge discovery
- essential proteins
- data mining
- interacting proteins
- data acquisition
- feature selection