Intermediate Monitoring, Sample Size Reassessment, and Multi-Treatment Optimal Response-Adaptive Designs for Phase III Clinical Trials with More Than One Constraint.
Atanu BiswasPinakpani PalPublished in: Commun. Stat. Simul. Comput. (2009)
Keyphrases
- sample size
- clinical trials
- experimental design
- worst case
- cancer patients
- model selection
- statistical power
- random sampling
- upper bound
- disease progression
- small sample
- variance reduction
- small samples
- decision support system
- optimal solution
- lower bound
- clinical guidelines
- breast cancer
- statistical hypothesis testing
- progressive sampling
- data warehouse
- data sets
- breast cancer patients