How oligoclonal are germinal centers? A new method for estimating clonal diversity from immunohistological sections.
José FaroMichal Or-GuilPublished in: BMC Bioinform. (2013)
Keyphrases
- significant improvement
- cost function
- computationally efficient
- high precision
- high accuracy
- pairwise
- probabilistic model
- data sets
- particle swarm optimization
- fully automatic
- synthetic data
- clustering method
- preprocessing
- support vector
- similarity measure
- theoretical analysis
- support vector machine svm
- evolutionary algorithm
- detection method
- segmentation method