A method for probing the mutational landscape of amyloid structure.
Charles W. O'DonnellJérôme WaldispühlMieszko LisRandal HalfmannSrinivas DevadasSusan LindquistBonnie BergerPublished in: Bioinform. (2011)
Keyphrases
- high accuracy
- significant improvement
- fully automatic
- similarity measure
- high precision
- experimental evaluation
- preprocessing
- data sets
- computational complexity
- pairwise
- cost function
- dynamic programming
- mutual information
- main contribution
- mathematical model
- synthetic data
- segmentation algorithm
- graph structure
- data structure
- tree structure
- clustering method
- detection algorithm
- optimization algorithm
- evolutionary algorithm
- computational cost
- prior knowledge