Selectivity by Small-Molecule Inhibitors of Protein Interactions Can Be Driven by Protein Surface Fluctuations.
David K. JohnsonJohn KaranicolasPublished in: PLoS Comput. Biol. (2015)
Keyphrases
- protein interaction
- protein protein interactions
- protein interaction data
- computational methods
- predicting protein
- protein function
- biological processes
- protein interaction networks
- gene ontology
- functional modules
- protein complexes
- biomedical literature
- high throughput
- biological data
- systems biology
- network topology
- high precision
- gene expression
- structural properties
- cellular processes
- protein protein interaction networks
- databases
- biological knowledge
- statistical methods
- genomic data
- biological systems
- binding sites
- ad hoc networks
- computational approaches
- drug discovery
- microarray
- biological networks
- text mining