Synthetic protein alignments by CCMgen quantify noise in residue-residue contact prediction.
Susann VorbergStefan SeemayerJohannes SödingPublished in: PLoS Comput. Biol. (2018)
Keyphrases
- contact map
- contact maps
- protein structure prediction
- protein chains
- amino acids
- protein structure
- sequence alignment
- protein sequences
- protein functional
- amino acid sequences
- random noise
- pairwise
- drug design
- protein homology
- noisy data
- neural network
- coarse grained
- noise reduction
- multiple sequence alignment
- real world
- protein function
- fine grained
- computational biology
- noise level
- signal to noise ratio
- secondary structure
- protein protein interactions
- prediction accuracy
- multiple sequence alignments
- subcellular localization
- median filter
- amino acid residues