Protein Language Model-Powered 3D Ligand Binding Site Prediction from Protein Sequence.
Shuo ZhangLei XiePublished in: CoRR (2023)
Keyphrases
- protein protein
- language model
- protein sequences
- binding sites
- experimentally determined
- predicting protein
- protein protein interactions
- protein secondary structure
- drug design
- protein structure prediction
- computational methods
- protein function
- protein structure
- protein classification
- protein interaction
- computational biology
- amino acids
- interaction networks
- probabilistic model
- multiple sequence alignments
- information retrieval
- prediction accuracy
- remote homology detection
- high throughput
- secondary structure
- biological sequences
- protein complexes
- amino acid sequences
- dna sequences
- contact map
- gene expression
- sequence analysis
- sequence alignment
- sequence data
- structural motifs
- virtual screening
- motif discovery
- biological networks
- statistical significance
- molecular biology
- physico chemical
- solvent accessibility
- transcription factors
- network topology
- computational approaches
- psi blast
- drug discovery
- machine learning