Dosing time optimization of antihypertensive medications by including the circadian rhythm in pharmacokinetic-pharmacodynamic models.
Javiera Cortés-RíosRamón C. HermidaMaria Rodriguez-FernandezPublished in: PLoS Comput. Biol. (2022)
Keyphrases
- probabilistic model
- complex systems
- statistical models
- autoregressive
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- search algorithm
- optimization problems
- optimization algorithm
- global optimization
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- response surface
- anatomical structures
- constrained optimization
- optimization process
- mathematical models
- neural network model
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